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2 edition of Characterization of the cytochrome P450 4A subfamily found in the catalog.

Characterization of the cytochrome P450 4A subfamily

Pamela Jean Castle

Characterization of the cytochrome P450 4A subfamily

isoforms in liver and kidney from human and rat

by Pamela Jean Castle

  • 136 Want to read
  • 10 Currently reading

Published .
Written in English

    Subjects:
  • Cytochrome P-450 -- Analysis.,
  • Liver -- Physiology.,
  • Kidneys -- Physiology.,
  • Immunochemistry.

  • Edition Notes

    Other titlesCharacterization of the cytochrome P-450 4A subfamily.
    Statementby Pamela Jean Castle.
    The Physical Object
    Paginationx, 82 leaves, bound :
    Number of Pages82
    ID Numbers
    Open LibraryOL17004333M

      Pharmacogenetics of cytochrome P (CYP) in the elderly. Ageing Research Reviews , 9 (4), DOI: / Shu-Feng Zhou, Jun-Ping Liu, Balram Chowbay. Polymorphism of human cytochrome P enzymes and its clinical impact. Four genes in the P IID gene subfamily were isolated from Sprague-Dawley rat λEMBL 3 and Charon 4A genomic libraries and completely sequenced. Their transcription start sites were determined by primer extension analysis. The four genes designated IID2, IID3, IID4, and IID5 span , , , and bp, respectively, and are closely linked head to tail on a 60 .

    Ensembl ENSG ENSMUSG UniProt Q O RefSeq (mRNA) NM_ NM_ NM_ NM_ RefSeq (protein) NP_ NP_ NP_ NP_ Location (UCSC) Chr 1: – Mb Chr 4: – Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cytochrome P . We next examined the known mouse members of the P subfamily 4A (Ps 4a, 4a, and 4a) with respect to their intrarenal localization. Isoform-specific oligonucleotides were designed and tested in Southern blots with the individual P cDNAs for their specificity (data not shown) and were used for in situ hybridization.

    The human P enzymes encoded by CYP4 genes (see ) represent a distinct lineage of the P family. The CYP4A subfamily is involved in the metabolism of medium- and long-chain fatty acids (Cho et al., ).   CYTOCHROME P (CYP) is a collective term that is used to describe a superfamily of haem proteins gh there are a few exceptions, most of these enzymes are monooxygenases, which catalyse.


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Characterization of the cytochrome P450 4A subfamily by Pamela Jean Castle Download PDF EPUB FB2

The Cytochrome P 4A subfamily is one of eighteen subfamilies in the CYP4 family and Presently consists of twenty individual forms in nine different mammalian species.

The major substrates for CYP4A forms are fatty acids, but recent studies have shown other non-fatty acid substrates may be metabolized by specific CYP4A by:   Cloning and characterization of a novel member of the cytochrome P subfamily IVA in rat prostate.

DNA Cell Biol. Oct; 9 (8)– Nhamburo PT, Gonzalez FJ, McBride OW, Gelboin HV, Kimura S. Identification of a new P expressed in human lung: complete cDNA sequence, cDNA-directed expression, and chromosome mapping.

by: Cytochrome P aromatic O-demethylase, which is made of two distinct promiscuous parts: a cytochrome P protein (GcoA) and three domain reductase, is significant for its ability to convert Lignin, the aromatic biopolymer common in plant cell walls, into renewable carbon chains in a catabolic set of reactions.

In short, it is a facilitator of InterPro: IPR   A cDNA clone (PP1) encoding a part of a novel form of cytochrome P was isolated and the deduced amino acid sequence showed 76% identity with cytochrome P IVA1, indicating that PP1 is a member of the same by:   P 4X1 and 4Z1 appear to share some of the regulatory properties of the 4A subfamily, and P 4Z1 was found to be preferentially expressed in carcinoma of the breast.

Presently no other information about the expression or possible activities of the other enzymes has been reported (2W1, 4A22, 4F22, 20A1, and 27C1).Cited by: Cytochrome P, family 3, subfamily A, also known as CYP3A, is a human gene locus. A homologous locus is found in mice. The CYP3A locus includes all the known members of the 3A subfamily of the cytochrome P superfamily of genes.

These genes encode monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of. Journals & Books; Help Vol Issue 1, 5 JulyPages Characterization of dextromethorphan N-demethylation by human liver microsomes: Contribution of the cytochrome P 3A (CYP3A) subfamily. Author links open overlay panel opher Gorski.

The cytochromes P (abbreviated to Ps or CYPs) are a large enzyme class, predominantly formed of monooxygenase enzymes. They are found across nature from archaea and prokaryotes through to higher eukaryotes and man (Denisov, Makris, Sligar, & Schlichting, ; Munro, Girvan, Mason, Dunford, & McLean, ).The majority of these enzymes.

1. Introduction. Cytochrome P (CYP) is a heme-containing enzyme superfamily containing more than isoforms in the natural world.CYP enzymes play an important role in the metabolism of a variety of endogenous and exogenous compounds including prescription drugs, pollutants, carcinogens and fatty 57 CYP isoforms in humans.

Introduction. The cytochrome P, family 2, subfamily C, polypeptide 19 (CYP2C19) gene is located within a cluster of cytochrome P genes (centromere-CYP2CCYP2CCYP2C9-CYP2C8-telomere) on chromosome 10qThe CYP2C19 enzyme contributes to the metabolism of a large number of clinically relevant drugs and drug classes such as.

Introduction. Cytochrome P, family 2, subfamily C, polypeptide 8 (CYP2C8) is a phase I metabolizing enzyme that plays an integral role in the biotransformation of structurally diverse xenobiotics and endogenous compounds [].CYP2C8 accounts for 7% of the CYP content in the liver and is expressed to a lesser extent in the kidney, adrenal gland, mammary gland, brain, Cited by:   Identification of a novel cytochrome P enzyme that catalyzes the C-2α hydroxylation of pentacyclic triterpenoids and its application in yeast cell factories Author links open overlay panel Zhubo Dai a b 1 Yun Liu a b 1 Zhoutong Sun a 1 Dong Wang a b Ge Qu a Xiaolin Ma a c Feiyu Fan a b Lili Zhang a c Shoulian Li a c Xueli Zhang a b.

Choi D.H., Li C., Choi J.S. Effects of myricetin, an antioxidant, on the pharmacokinetics of losartan and its active metabolite, EXP, in rats: possible role of cytochrome P 3A4, cytochrome P 2C9 and P-glycoprotein inhibition by myricetin.

J Pharm Pharmacol. ; –   Functional characterization of cytochrome P CYP81A subfamily to disclose the Bishop G, Hamberger B, Höfer R, Paquette S, Werck-Reichhart D () Cytochromes P Arabidopsis Book 9:e Fukunishi, K.

et al. Functional characterization of cytochrome P CYP81A subfamily to disclose the pattern of cross-resistance in. The complement of the various cytochrome P enzymes in a given individual varies markedly, and dramatic differences may be seen in drug metabolism, pharmacological response, and susceptibility to toxic effects.

The cytochrome P monooxygenases (Ps) are a large and complex gene superfamily of heme-thiolate proteins that are found in almost all living organisms Ps can be divided into four. Citation: Cai H, Jiang J, Yang Q, Chen Q, Deng Y () Functional Characterization of a First Avian Cytochrome P of the CYP2D Subfamily (CYP2D49).

PLoS ONE 7(6): e doi/journal. Overview. CYP2J2 is a member of the cytochrome P (CYP) family of monooxygenases, and, in humans, is the sole member of the CYP2J subfamily [].Specifically, CYP2J2 is an epoxygenasethat catalyzes epoxideformation at thesite of a carbon–carbon double bond in the substrate, as other CYP epoxygenases do, such as CYP2C8 and CYP2C9 [].The therapeutic Cited by: Characterization of human cytochrome P enzymes.

FASEBJ ;6: Tolbutamide and mephenytoin hydroxylation by human cytochrome Ps in the CYP2C subfamily. J Pharmacol Exp Ther ; Book Review: Cytochrome P and Active Oxygen Show details.

Idiotypes of DNA-Binding Antibodies: Recent Advances. The cytochrome P (CYP) enzymes display interindividual and interethnic variability that may alter the disposition of substances metabolised by these enzymes.

Both genetic and environmental factors such as concomitant drug use and concurrent. The body of an organism has a powerful system to facilitate the excretion of potentially harmful substances: the cytochrome P system.

Cytochrome P stands for a superfamily of more than 50 closely related heme-containing enzymes, which can be divided into families (with at least 40 % sequence homology on the amino acid level) and subfamilies (with at least 55 % .Function. This gene encodes a member of the cytochrome P superfamily of enzymes.

The cytochrome P proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, fatty acids, and other protein localizes to the endoplasmic enzyme starts the process of inactivating and .Purchase Cytochrome P, Volume - 1st Edition.

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